FLT4 and lymphedema: This is associated with several gene mutations such as VEGFR-3 (Milroy disease), SOX18 (hypotrichosis-telangiectasia-lymphedema), CCBE (Hennekam syndrome), and FOXC2 (lymphedema distichiasis) (Maclellan and Greene, 2014; Kambhampati et al., 2016).