Recently, two studies found that the expression of USP7 was significantly increased under hypoxia in cardiomyocytes, while its inhibition or knockdown of USP7 can protect the heart from hypoxia-induced cardiomyocyte injury or myocardial ischemia/reperfusion injury (Xue et al., 2021; Xu et al., 2022). Here, USP7 is linked to myocardial ischemia.