AGT and cardiac hypertrophy: Moreover, the Ang II-induced cardiac hypertrophy, fibrosis and inflammation, which can be activated by ROS, were also attenuated with the treatment of USP7 inhibitor p22077 (Figures 4, 5), suggesting that the protective effect of p22077 on the Ang II-induced cardiac hypertrophy, fibrosis and inflammation may be related to oxidase stress.