Several liver-related inflammatory diseases, especially chronic hepatitis C, nonalcoholic steatohepatitis, alcoholic liver disease, and IDILI have been reported to be associated with NLRP3 inflammasome activation (Csak et al., 2011; Burdette et al., 2012; Petrasek et al., 2012; Wree et al., 2014a; Wree et al., 2014b; Voican et al., 2015; Kato and Uetrecht, 2017). This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatohepatitis.