Besides its efficacies for controlling hyperglycemia in T2D, GPR40 agonists have also been shown to be potentially applicable for other indications, including obesity and NASH, inflammatory bowel diseases, neurodegenerative diseases, etc. GPR40 plays an important role in regulating GLP-1 and other intestine incretin secretion. The gene discussed is GLP1R; the disease is metabolic dysfunction-associated steatohepatitis.