NPPB and congestive heart failure: Several previous prospective clinical studies (Wang et al., 2019; Zhao et al., 2019; Lu et al., 2020) have shown that combining XBP therapy with conventional therapy appears to be beneficial in improving cardiac function (e.g., increasing LVEF, and decreasing LVEDD and LVESD), decreasing BNP levels, and increasing 6MWT in patients with CHF.