In this study, we generated a humanized anti-CD147 antibody, h4#147D, and found that the h4#147D antibody showed strong antitumor effects with tumor regression in three SOC drug-insensitive mouse xenograft models using MIA PaCa-2 PDAC, Hep G2 HCC, and KU812 CML cell lines. This evidence concerns the gene BSG and neoplasm.