SERCA3 is a protective factor in most cancers, HR and 95%CI for cancers were PAAD (0.68, 0.56–0.81), CESC (0.85, 0.72–0.99), SKCM (0.86, 0.80–0.93), SARC (0.81, 0.71–0.92), BLCA (0.89, 0.80–0.98), SKCM-M (0.87, 0.80–0.95), COADREAD (0.80, 0.69–0.94), HNSC (0.87, 0.79–0.95), KIRC (0.87, 0.75–0.99), COAD (0.83, 0.70–0.99), OV (0.92, 0.84–1.00), while SERCA3 is an adverse factor in KIPAN (1.11, 1.00–1.22), GBMLGG (1.53, 1.38–1.70), TGCT (3.20, 0.94–10.88), UVM (2.04, 1.39–3.01), LGG (1.53, 1.33–1.76). The gene discussed is ATP2A3; the disease is cancer.