The chronic exposure to aversive and stressful events, especially during early life phases, is indeed known to exacerbate the behavioral symptoms of FXS patients (Hessl et al., 2001; Dyer-Friedman et al., 2002) and to anticipate the appearance of certain behavioral deficits in Fmr1-KO mice (Petroni et al., 2022). Here, FMR1 is linked to fragile X syndrome.