In addition, very recent work indicated that brain samples from TDP-43 proteinopathies as well as tauopathies and synucleinopathies are characterized by amyloid fibrils consisting of a 135-amino acid C-terminal fragment of transmembrane protein 106B (TMEM106B) (Chang et al., 2022; Jiang et al., 2022; Schweighauser et al., 2022). This evidence concerns the gene TMEM106B and synucleinopathy.