This predominantly nuclear protein that was known to bind the TAR element of the human immunodeficiency virus has since been implicated in the pathogenesis of multiple neurodegenerative diseases collectively known as TDP-43 proteinopathies (de Boer et al., 2020; Huang et al., 2020; Carlos and Josephs, 2022). Here, TARDBP is linked to neurodegenerative disease.