One mechanism of disease recently implicated in ALS and FTLD-TDP links the loss of nuclear TDP-43 to mis-splicing and depletion of stathmin 2 (STMN2), a regulator of the microtubule cytoskeleton (Klim et al., 2019; Melamed et al., 2019; Prudencio et al., 2020; Pickles et al., 2022). This evidence concerns the gene STMN2 and amyotrophic lateral sclerosis.