On the other hand, more recent work has suggested that overexpression of full length TDP-43 that localizes to the nucleus (but not TDP-43 lacking the nuclear localization signal) can elevate NEAT1_1 expression in SH-SY5Y neuroblastoma cells and in the central nervous systems (CNS) cortex of a mouse model (Matsukawa et al., 2021). Here, TARDBP is linked to neuroblastoma.