TARDBP and proteostasis deficiencies: Given that key features of TDP-43 proteinopathy include clearance of the protein from the nucleus with concomitant accumulation and aggregation in the cytoplasm (Arai et al., 2006; Neumann et al., 2006), it was notable that silencing of TDP-43 in SH-SY5Y neuroblastoma cells raised the number of paraspeckles per nucleus and expression of the paraspeckle-specific NEAT1 isoform, NEAT1_2 (Shelkovnikova et al., 2018).