More importantly, because TDP-43 can enhance miRNA biogenesis (Buratti et al., 2010; Kawahara and Mieda-Sato, 2012), the formation of paraspeckles in TDP-43-deficient neuroblastoma cells appears to serve a protective role by marshaling the pri-miRNA processing machinery to sustain the generation of miRNAs that target pro-apoptotic genes (Bottini et al., 2017; Jiang et al., 2017; Shelkovnikova et al., 2018). This evidence concerns the gene TARDBP and neuroblastoma.