TARDBP and Alzheimer disease: Several studies have observed TDP-43 immunoreactivity in a subset of AD cases with neuroanatomical distribution pattens that were broadly distinct from those observed in FTLD (Amador-Ortiz et al., 2007; Higashi et al., 2007; Uryu et al., 2008; Arai et al., 2009; Kadokura et al., 2009; King et al., 2010; Davidson et al., 2011; McAleese et al., 2017).