TARDBP and amyotrophic lateral sclerosis: On the other hand, Shelkovnikova et al. (2018) recently observed paraspeckles in a small cohort of ALS patients (two with TDP-43 pathology, four with C9ORF72 pathology, and seven with sporadic ALS), with ∼30% of spinal cord neurons displaying paraspeckles compared to no paraspeckles in neurons from healthy control patients.