UNC13A and amyotrophic lateral sclerosis: More recently, 12 additional genomic loci have been implicated in ALS by genome-wide association studies (GWAS), including KIF5A, GPX3, TNIP1, and UNC13A (van Rheenen et al., 2016, 2021; Benyamin et al., 2017; Nicolas et al., 2018).