In addition to animal models, autopsy results of AD patients showed down-regulation of GPX4, up-regulation of arachidonic acid 12/15 lipoxygenase (ALOX15), and enhanced lipid peroxidation, and 4-hydroxynonenal (4-HNE) in AD patient brains was elevated (Yoo et al., 2010). Here, ALOX15 is linked to Alzheimer disease.