Clinically, ferroptosis can be induced by the following methods and exert a neuroprotective effect: exogenous lipid supplementation promotes lipid peroxidation in cells; inhibition of GPX4 and expression of GSH; construction of nano-drug delivery system to supplement hydrogen peroxide and iron ions to promote Fenton reaction of tumor cells, etc. Therefore, ferroptosis is a potential target for the treatment of neurodegenerative diseases. Here, GPX4 is linked to neurodegenerative disease.