IDUA and Scheie syndrome: Furthermore, the human α-L-iduronidase gene (Idua) can be detected in multiple brain regions, including the hippocampus, corpus callosum, cortex, caudate-putamen, and cerebellar Purkinje cell layer after ICV injection of rAAV8-Idua in a neonatal MPS I mouse model, and this reduces the accumulation of glycosaminoglycan and prevents cognitive dysfunction (Wolf et al., 2011).