Dermal periostin is upregulated in patients with both AD and prurigo nodularis (PN, a chronic, inflammatory skin condition characterized by itchy nodules), and also induces allergic itch in mice, dogs and non-human primates via integrin αVβ3 (Kou et al., 2014; Sung et al., 2017; Mishra et al., 2020; Hashimoto et al., 2021c). This evidence concerns the gene POSTN and Pruritus.