TRPV3 and Pruritus: For example, as discussed previously, TRPV3 is implicated in pruritus and its expression in HEK293T cells has provided a successful means for identifying inhibitors, such as the oral anesthetic dyclonine (found in throat sprays and lozenges), and the tropical plant-based acridone citrusinine-II (Han et al., 2021; Liu et al., 2021).