Loss-of-function mutations in ABCA7 are also prevalent in AD (Hollingworth et al., 2011; Steinberg et al., 2015) with evidence of TDP-43 positive neurofibrillary tangles and neuronal cytoplasmic inclusions in these cases (Van den Bossche et al., 2016) despite lower protein levels. This evidence concerns the gene TARDBP and Alzheimer disease.