Interestingly, rare variants of the ABCA7 gene have been identified in two sporadic cases of FTD (Ciani et al., 2019) and a homozygous loss-of-function ABCA7 variant was also identified, suggesting ABCA7 as a candidate gene for monogenic FTD (Wagner et al., 2021). Here, ABCA7 is linked to frontotemporal dementia.