Since neuroinflammation is widely considered as a hallmark of neurodegenerative diseases and its role in the aetiology of FTLD is of increasing interest (Bright et al., 2019), the relationship between neuroinflammation, TARDBP and ABCA4 and ABCA13 should be further examined to determine if these ABCA transporters exhibit neuroprotective or more neurotoxic roles. The gene discussed is TARDBP; the disease is neurodegenerative disease.