POLR3A and lipodystrophy: In addition, a variant of WDRTS was reported to have some atypical WDRST features (such as no lipodystrophy, no natal teeth and no sparse scalp hair), which was caused by a homozygous mutation in POLR3GL (c.358C > T, p.Arg120Ter) (Beauregard-Lacroix et al., 2020).