TBP and spinocerebellar ataxia type 17: In the case of SCA17, earlier attempts to associate caspases with the cleavage of the disease protein TBP were inconclusive, despite unequivocal reports on the involvement of truncated forms of polyQ-expanded TBP in the molecular pathology of SCA17 (Wellington et al., 1998; Friedman et al., 2008).