DNM1L and ischemic stroke: Under homeostatic states, Drp-1 is allocated in the cytoplasm, whereas during ischemic stroke, Drp-1 is activated by dephosphorylation at Ser637, thereby promoting the recruitment of Drp-1 to the mitochondria via its receptor proteins, mitochondrial fragmentation, and exacerbated apoptotic cell death after ischemic stroke (Flippo et al., 2020; Tian et al., 2022).