In order to study the relationship of CUL4B in the development of CRC, we analysed the difference in expression of CUL4B between tumour tissue and normal tissue adjacent to the tumour (NAT) in TCGA, and found that the expression of CUL4B in tumours was significantly higher than that of its NAT (Figure 4A). The gene discussed is CUL4B; the disease is neoplasm.