Pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 are elevated in the brains of people with AD, leading to the accumulation of Aβ plaque aggregates and tau hyperphosphorylation, resulting in neuronal loss (Kinney et al. 2018; Wang et al. 2015); thus, this study is conducted on decreasing NF-κβ which is a key mediator of these pro-inflammatory cytokines. The gene discussed is MAPT; the disease is Alzheimer disease.