ACHE and Alzheimer disease: Although the elevation of AChE is a non-specific marker of disrupted cholinergic function as it is located both on cholinergic presynaptic and on non-cholinergic postsynaptic elements, however, it is worthy here to denote that the elevation of AChE together with both decline of spatial learning and memory and apparent histopathological loss of non-cholinergic postsynaptic neurons represented in the hippocampal tissues of AlCl3-induced AD rats’ model refers to disrupted cholinergic system.