BDNF and obesity due to melanocortin 4 receptor deficiency: As pointed out in a systematic review9 and a meta-analysis7, studies regarding accelerometer-measured habitual PA and SB and resting BDNF in non-healthy adults (e.g., obesity, CVD, diabetes) are limited and pattern variables of PA and SB (e.g., sedentary bouts) were rarely reported in these studies.