ACLY and cancer: In ovarian tumors, upregulation of USP13 enhances deubiquitination and stabilization of ACLY (ATP citrate lyase) and OGDH (oxoglutarate dehydrogenase), two key enzymes that drive glutaminolysis, ATP generation, and lipid synthesis in cancer metabolism89, and MCL1, a pivotal member of the antiapoptotic BCL-2 family of proteins91,92.