OTUD3 and cancer: Indeed, HAUSP/USP7, Ataxin-3, USP10, USP11, USP13, and OTUD3 have all been identified as PTEN DUBs; HAUSP specifically removes monoubiquitin from PTEN to promote its nuclear export41; Ataxin-3 restricts PTEN transcription42; and USP10, USP11, USP13 and OTUD3 increase PTEN stability in different cancer-specific contexts43–45.