Indeed, HAUSP is overexpressed and associated with unfavorable prognosis in many different types of human cancers, including brain, breast, cervical, lung, prostate, skin, stomach, and hemopoietic cancers41,54,58–63, and high HAUSP expression and PTEN nuclear exclusion are strongly and positively correlated in human cancers41,58,64,65. Here, PTEN is linked to cancer.