MFGE8 and early-onset autosomal dominant Alzheimer disease: To this end, we examined MFGE8 gene expression in dorsolateral prefrontal cortex samples from 566 patients in the ROSMAP cohort23 (focussing on those with Alzheimer’s disease as the only known cause of cognitive impairment—that is, final clinical consensus diagnosis of cognitive status (cogdx) 1 versus 2 versus 4 (ref. 24)).