MFGE8 and early-onset autosomal dominant Alzheimer disease: Notably, MFGE8 expression was significantly increased in patients with Alzheimer’s disease (85.9 ± 3.7 years of age; 69% female) compared with controls without dementia (82.9 ± 5.0 years of age; 61% female) (Fig. 2h and Supplementary Table 2).