Moreover, we observed a significant downregulation in MKI67 expression in F. nucleatum-exposed cancer spheroids (Supplementary Table 11), consistent with the downregulation of Ki-67 in bacteria-colonized microniches that was observed in the DSP analysis from patient tumours (Fig. 2) and the negative correlation with bacterial load that was observed in the whole-sample analysis from the scRNA-seq data (Extended Data Fig. 7a). The gene discussed is MKI67; the disease is cancer.