ITGB4 and non-small cell lung carcinoma: KCNF1 knockdown in NSCLC cells, A549 and H23, decreased ITGB4 expression and resulted in reduced phosphorylation of focal adhesion kinase FAK and AKT (Fig. 7A), which are downstream events enhanced by the cooperation between α6β4 integrin and oncogenic receptor tyrosine kinase [29, 30].