KCNF1 and cancer: Although we cannot completely rule out that regulation of cell growth and cancer progression by KCNF1 relies on ionic conduction, our results implicate that it likely functions through a non-conducting mechanism as endogenous KCNF1 and exogenous KCNF1-EGFP were detected in the ER/Golgi and nucleoplasm, but not on the plasma membrane where Kv subunits normally function.