Thus, we monitored the expression of Lgr5+ intestinal stem cells in intestinal tissues of each experimental group [19], and found that the number of Lgr5+ intestinal stem cells in the NEC group was sharply reduced compared with the WT group (Fig. 1F, G), but after the intervention treatment with AFSC-exos and HBM- exos, the number of Lgr5+ intestinal stem cells increased significantly (Fig. 1F, G). Here, LGR5 is linked to necrotizing enterocolitis.