CD274 and neoplasm: For instance, T lymphocytes with increased intracellular L-arginine levels display enhanced survival and anti-tumor effector capacity [175], and tumor colonization with an Escherichia coli strain engineered to continuously convert ammonia to L-arginine increases the number of tumor-infiltrating T cells and synergizes with PD-L1 blockade in the clearance of tumors, in mice [176].