PARAGLIDE-HF is a multicentre, randomized, double-blind study to assess safety and tolerability of sac/val versus valsartan as well as its effect of NT-proBNP and outcomes in patients with HFpEF who have been stabilized during hospitalization and initiated sac/val in-hospital or within 30-day post-discharge [67]. Here, NPPB is linked to hydrops fetalis.