PFKFB3 and cancer: Within the glycolytic pathway, both Hk2, which encodes the rate-limiting enzyme hexokinase, previously reported to be repressed by ZFP36 in human cancer cells60, and Pfkfb3, which converts fructose-6 phosphate to fructose-2,6 bisphosphate, an allosteric promoter of glycolysis, were bound at AREs within their 3’UTR (Supplementary Fig. S2a).