SOD1 and amyotrophic lateral sclerosis: SOD1-containing inclusions are hallmarks of ALS caused by SOD1 mutations [10, 23, 27, 43, 48], but patients heterozygous for dominantly inherited ALS-causing SOD1 mutations, e.g., SOD1G127X and SOD1A4V, have larger skein-like SOD1-containing inclusions (Fig. 1j) [23, 47].