SOD1 and frontotemporal dementia: The D90A SOD1 inclusions had a morphology and distribution similar to the inclusions staining positive for misfolded wild-type SOD1 in sALS patients (Fig. 1g) [20] and in patients with mutations in other ALS- and FTD-associated genes (Fig. 1h) [19], but differ from the SOD1 staining seen in neurons from patients carrying dominantly inherited SOD1 mutations, such as the SOD1A4Vhet mutation.