Finally, regarding the DMR, SNPs within the region comprising the associated genes SHC4 and EID1 have been related with psychiatric disorders such as major depressive disorder [47, 48], bipolar disorder [49], mood and psychotic disorders [50], obsessive compulsive disorder [51], and schizophrenia [52] (Supplementary Table 14) (Supplementary Fig. 4b). Here, SHC4 is linked to major depressive disorder.