Of all identified proteins (n = 67), nine were increased among patients with sepsis-AKI as compared to sepsis (DEP fold change > 2, p-value < 0.05) and at the same time correlated with PC1, PC2 or both (Fig. 2A), namely: calcitonin gene related peptide 1 (CALCA), calreticulin (CALR), carbonic anhydrase 12 (CA12), c-type lectin domain family 1 member (CLEC1A), inactive tyrosine protein kinase 7 (PTK7), kidney injury molecule-1 (KIM-1), natriuretic peptide precursor C (NPPC), nucleobindin-2 (NUCB2) and prostaglandin F2 alpha receptor (PGF). This evidence concerns the gene CA12 and acute kidney injury.