GPER1 and colorectal carcinoma: Importantly, we could validate these results obtained from HCT116 in another CRC cell line, that is, HCT-15, and also in non-transformed CCD 841 CoN colon epithelial cells after the inhibition of GPER1 by the selective GPER1 antagonist G15 (Figs 6D and F and S6F and G).