CASP8 and neoplasm: And cluster 3 subtype showed a high expression of AIM2, CASP1, CASP3, CASP5, CASP6, CASP8, GSDMB, IL18 and TIRAP, whose pyroptosis characterization, regulated by this gene set, resulted in an improved prognosis and immune-inflamed tumor microenvironment (Figure 2D, 2E).