We found that the EDIN-B-expressing ST80 WT strain thoroughly altered the organization of the actin cytoskeleton as early as 30 min post-infection and prevented the formation of actin fibers, whereas actin fibers were neither disrupted nor hindered by the ST80 ΔedinB strain (Fig. 7A), which reflects the ability of EDIN-B to inhibit RhoA. The gene discussed is RHOA; the disease is infection.