M42 is strongly related to amyloid deposition [2, 38], and the fact that CSF and plasma SMOC1 did not correlate with cognitive function is consistent with this association given that amyloid also does not strongly correlate with cognitive function [39] and M42 levels are not an independent driver of cognitive decline after adjustment for AD neuropathology [2]. The gene discussed is SMOC1; the disease is Mental deterioration.