M8 module eigenprotein levels were strongly negatively correlated with cognitive function (r= –0.67) and Aβ42/tau ratio (r= –0.82), and strongly positively correlated with total tau (r=0.86) and p-tau181 (r=0.78) (Fig. 8C), reflecting its close association to AD brain amyloid-β and tau pathology. Here, MAPT is linked to Alzheimer disease.