We also tested specificity of SMOC1 for AD by measuring SMOC1 CSF levels using TMT-MS in a separate cohort comprised of control, AD, ALS, FTD, and PD subjects as previously described in Higginbotham et al. [7] Elevation of SMOC1 in CSF was specific to AD. This evidence concerns the gene SMOC1 and amyotrophic lateral sclerosis.