Screening for ovarian cancer using transvaginal sonography and cancer antigen 125 (CA125) has been proven ineffective in the general population3 and in women at increased inherited risk.5 Lately, instead of focusing on macroscopic changes, there is increasing interest in detecting microscopic (pre)malignant cells that detach along the Müllerian ducts. The gene discussed is MUC16; the disease is ovarian carcinoma.