Combined with the results of our study, as a marker of tumor growth, the relationship between Ki-67 and COX-2 and VEGF may be due to the performance of COX-2 and VEGF promoting tumor growth, but it can not be ruled out that COX-2 or VEGF have some effects on Ki-67, which needs to be verified by follow-up experiments. This evidence concerns the gene PTGS2 and neoplasm.