GAPDH and viral infectious disease: In addition, during Covid-19 and other viral infections [59–61], there is a reprogramming of the glucose metabolism that overexpress glycolitic enzymes as glyceraldehyde 3-phosphate dehydrogenase - GAPDH (enriched in Fig. 2 C) in non-immune and immune cells, specially the ones involved in innate immunity - which are activated [54, 62].