Each SD higher circulating IL6 (IL6) level was associated with higher risk of MS (NSNP = 2; ORIVW 2.45; 95% CI 2.05–2.93; pIVW = 1.3 × 10−22), but lower risk of RA (NSNP = 1; ORWald 0.54; 95% CI 0.43–0.67; pWald = 1.3 × 10−8). The gene discussed is IL6; the disease is rheumatoid arthritis.