Nevertheless, the top signal identified for AD (circulating MIG [CXCL9] level [NSNP = 2; ORIVW 1.23; 95% CI 1.06–1.42; pIVW = 0.007]) also was a suggestive causal biomarker for Crohn disease (NSNP = 2; ORIVW 0.73; 95% CI −0.62 to 0.86; pIVW = 1.3 × 10−4). This evidence concerns the gene CXCL9 and Alzheimer disease.