In another research, it was discovered that CD8+ TILs express PD-1, TIM-3 (a co-inhibitory receptor restricted to IFN-γ-producing T cells), and LAG-3 (an inhibitory receptor), which can be used to identify the autologous tumor-reactive repertoires, including mutant neoantigenic T cells [112]. This evidence concerns the gene PDCD1 and neoplasm.