In subjects aged ≤ 59 years, RAD54L2 rs11720298 was related to a reduced susceptibility to lung cancer, whereas several risk-increasing associations of RAD54L2 rs4687592 (OR = 0.69, p = 0.012), RAD54L2 rs9864693 (OR = 1.64, p = 0.012) and GTF2H1 rs4150667 (OR = 1.32, p = 0.048) with lung cancer were found. The gene discussed is RAD54L2; the disease is lung cancer.