After whole genome sequencing of 48 affected individuals from this family, the chromosomal translocation (1;11)(q42;q14.3) was discovered to disrupt three genes: DISC1, DISC2 and DISC1FP. These gene disruptions were identified as highly penetrant with negative impacts on cognitive ability, neurodevelopment, and increased risk of psychiatric disorders [47]. This evidence concerns the gene DISC1 and psychiatric disorder.