There is emerging evidence of hyperglycemia induced increase in surface glucose-regulated protein (GRP78) expression on the endothelium, which in turn not only facilitates SARS CoV-2 entry by forming a complex with spike protein and angiotensin converting enzyme 2 (ACE2) receptors, but also mediates interaction with Mucorales spores through spore protein homologue CotH3 and promotes endothelial invasion [26, 27]. This evidence concerns the gene ACE2 and Hyperglycemia.