Although previous and our studies are showing that circulating levels of GHBP are increased in children with obesity [30–32] and that IGF-1 serum levels are increased in children with overweight/obesity during pre-puberty and/or early puberty [2,30,33–36], it is not clear whether expression of IGF-1 or GHR/GHBP in AT directly contributes to these alterations in serum levels. This evidence concerns the gene GHR and obesity due to melanocortin 4 receptor deficiency.