The positions of the two distal regions were also chosen in part because they overlap putative TF-binding sites belonging to known transcriptional activator Zinc Finger Protein X-Linked (ZFX) nested within enriched euchromatin (active) histone marker H3K27ac, as revealed by ChIP-seq data from the Encyclopaedia of DNA Elements (ENCODE) repository in CRC cell line HCT116 [36]. The gene discussed is TF; the disease is colorectal carcinoma.