SPRY4 and colorectal carcinoma: The UCSC genome browser depiction of the epigenetic landscape of SPRY4 in CRC cell lines HCT116 and Caco2 determined that distal promoter regions #1 and #2 were potential regions of interest, considering differential methylation between Caco2 and HCT116 cells exists in both regions as indicated by 450K methylation probe data from ENCODE (Figure 5a).