Regulatory effects of PD-L1+ neutrophils have been shown in cancer and microbial infections (Bowers et al., 2014; Castell et al., 2019; Chun et al., 2015; de Kleijn et al., 2013; Langereis et al., 2017; Mcnab et al., 2011; Schulte-Schrepping et al., 2020). This evidence concerns the gene CD274 and cancer.