MTOR and neoplasm: Mutation of PBRM1 (p = 0.0003) and mutation of mTOR (p = 0.005) were also associated with increased HIF metagene scores in this tumor type, consistent with previous findings (Brugarolas et al., 2003; Gao et al., 2017; Hudson et al., 2002; Treins et al., 2002).