AGR2 and ileocolitis: In humans, the correlation of AGR2 expression with Enterobacteriaceae dysbiosis may reflect a compensatory response to increased ER stress triggered during CD or increased expression of non-functional variants.22 Supporting this association with increased ER stress, our results in Agr2-deficient mice with increased ER stress and spontaneous ileocolitis revealed Enterobacteriaceae dysbiosis with specific enrichment of AIEC in the mucosal-associated microbiota.