4,30 To investigate whether AGR2 is associated with microbial dysbiosis in IBD, we performed an integrated analysis of matched host transcriptome and bacterial 16S rRNA sequencing data in treatment-naive patients with CD from the RISK Cohort Study (Risk Stratification and Identification of Immunogenetic and Microbial Markers of Rapid Disease Progression in Children with Crohn Disease).1,31 Patients with CD had higher AGR2 expression in ileal biopsies compared with non-IBD controls (Figure 1A). Here, AGR2 is linked to inflammatory bowel disease.