One of the mysteries about RyR2 channelfunction involves the observation that many different single aminoacid substitutions are capable of causing CPVT and/or LQTS symptoms.A listing of 63 possible CPVT1-associated RyR2 mutations was providedby Medeiros-Domingo et al.6 Of these, 49fall within the residue sequences included in the eight RyR2 modelsin our present study (Figure S2 and Table S5). Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.