Recessive nonsynonymous variants in MAP3K15 were nominally associated with reduced odds of diabetes (self-reported; OR = 0.81, 95% CI: [0.661, 0.996], P = 0.046; Fig. 2A and table S18) and were significantly associated with lower HbA1c levels (β = −0.11 SD units, 95% CI: [−0.18, −0.04], P = 2.2 × 10−3; Fig. 2B and table S19). The gene discussed is MAP3K15; the disease is diabetes mellitus.