MAP3K15 and diabetes mellitus: Our recessive collapsing model, which includes homozygous, hemizygous, and putative compound heterozygous carriers of nonsynonymous variants with a minor allele frequency (MAF) < 1%, identified a significant association between MAP3K15 and self-reported diabetes {odds ratio (OR) = 0.70, 95% confidence interval (CI): [0.62, 0.79], P = 5.0 × 10−9} (Table 1).