Fig 4 shows the difference in AUC ROC (Δ AUC ROC) achieved with the utilization of additional biomarkers: FDG PET (a single global marker of sugar metabolism), CSF (global markers of tau and amyloid burden), AV45 PET (a single global marker of brain amyloid load), MRI volumetric measurements (markers of brain atrophy). Here, MAPT is linked to Brain atrophy.